| First Author | Kisielow J | Year | 2001 |
| Journal | Eur J Immunol | Volume | 31 |
| Issue | 4 | Pages | 1141-9 |
| PubMed ID | 11298339 | Mgi Jnum | J:68809 |
| Mgi Id | MGI:1933476 | Doi | 10.1002/1521-4141(200104)31:4<1141::aid-immu1141>3.0.co;2-r |
| Citation | Kisielow J, et al. (2001) TARPP, a novel protein that accompanies TCR gene rearrangement and thymocyte education. Eur J Immunol 31(4):1141-9 |
| abstractText | Studies on thymic T cell development have usually concentrated on cell surface molecules. However, intracellular proteins expressed only in thymocytes have never been described. Here we report the discovery of a novel thymocyte-specific protein, named TARPP, which represents a high molecular mass ( approximately 100 kDa) variant of the previously identified protein ARPP-21 ( approximately 21 kDa). TARPP is a cytosolic protein that is expressed at high levels in immature thymocytes. It appears concomitant with the commitment to T cell lineage, and its expression is switched off as a consequence of TCR engagement during positive selection. Such an expression pattern, correlating with the rearrangement of the TCR genes and thymocyte education, suggests a role for TARPP during this important phase of thymocyte development. |
