| First Author | Perelygin AA | Year | 2002 |
| Journal | J Mol Evol | Volume | 55 |
| Issue | 2 | Pages | 202-10 |
| PubMed ID | 12107596 | Mgi Jnum | J:78588 |
| Mgi Id | MGI:2385431 | Doi | 10.1007/s00239-002-2318-0 |
| Citation | Perelygin AA, et al. (2002) Evolution of the mouse polyubiquitin-C gene. J Mol Evol 55(2):202-10 |
| abstractText | The polymeric ubiquitin (poly-u) genes are composed of tandem 228-bp repeats with no spacer sequences between individual monomer units. Ubiquitin is one of the most conserved proteins known to date, and the individual units within a number of poly-u genes are significantly more similar to each other than would be expected if each unit evolved independently. It has been proposed that the rather striking similarity among poly-u monomers in some lineages is caused by a series of homogenization events. Here we report the sequences of the polyubiquitin-C (Ubc) genes in two mouse strains. Analysis of these sequences, as well as those of the previously reported Chinese hamster and rat poly-u genes, supports the assertion that the homogenization of the ubiquitin-C gene in rodents is due to unequal crossing-over events. The sequence divergence of noncoding DNA was used to estimate the frequency of unequal crossing-over events (6.3 x 10(-5) events per generation) in the Ubc gene, as well as to provide evidence of apparent selection in the poly-u gene. |
