| Primary Identifier | IPR034887 | Type | Domain |
| Short Name | LARP7_RRM1 |
| description | This entry represents the RNA recognition motif 1 (RRM1) of La-related protein 7 (LARP7), an oligopyrimidine-binding protein that binds to the highly conserved 3'-terminal U-rich stretch (3' -UUU-OH) of 7SK RNA. LARP7 is a stable component of the 7SK small nuclear ribonucleoprotein (7SK snRNP) []. It intimately associates with all the nuclear 7SK and is required for 7SK stability []. LARP7 also acts as a negative transcriptional regulator of cellular and viral polymerase II genes, acting by means of the 7SK snRNP system. It plays an essential role in the inhibition of positive transcription elongation factor b (P-TEFb)-dependent transcription, which has been linked to the global control of cell growth and tumorigenesis [, ].LARP7 contains a La motif (LAM) and an RNA recognition motif (RRM1) at the N-terminal region, which mediates binding to the U-rich 3' terminus of 7SK RNA. LARP7 also carries another putative RRM domain at its C terminus. |
