| First Author | Allen RD 3rd | Year | 1999 |
| Journal | Genes Dev | Volume | 13 |
| Issue | 9 | Pages | 1073-8 |
| PubMed ID | 10323859 | Mgi Jnum | J:55049 |
| Mgi Id | MGI:1337180 | Doi | 10.1101/gad.13.9.1073 |
| Citation | Allen RD 3rd, et al. (1999) c-Myb is essential for early T cell development. Genes Dev 13(9):1073-8 |
| abstractText | The c-Myb transcription factor is important for fetal hematopoiesis and has been proposed to mediate later stages of lymphocyte development. Using homozygous null c-Myb/Rag1 chimeric mice, we have determined that c-Myb plays an important role in the differentiation of macrophages and lymphocytes from precursor stem cells. We also determine that deletion of c-Myb leads to a complete block in early T cell development just before the oligopotent thymocyte matures into the definitive T cell precursor. These data indicate that c-Myb plays an important role at multiple stages of hematopoiesis and is required at an early stage of T cell development. |
