| First Author | Fuchs E | Year | 1991 |
| Journal | Biochem Soc Trans | Volume | 19 |
| Issue | 4 | Pages | 1112-5 |
| PubMed ID | 1724430 | Mgi Jnum | J:12684 |
| Mgi Id | MGI:60920 | Doi | 10.1042/bst0191112 |
| Citation | Fuchs E (1991) Keratin genes, epidermal differentiation and animal models for the study of human skin diseases. Biochem Soc Trans 19(4):1112-5 |
| abstractText | The examples shown here illustrate the power of gene targeting to the epidermis as a means of developing animal models for the study of human skin diseases. In this short review, I have focused on contributions which stem predominantly from my own laboratory [31, 32, 34, 37, 47]. However, other laboratories have also contributed heavily to the development of this technology [28-30, 35, 36]. The opportunities for these models are vast: there are a myriad of human skin diseases which have been characterized extensively at a biological level, but whose aetiology is presently unknown. A combined knowledge of (a) the biochemistry of epidermal differentiation; (b) epidermal-specific gene expression; and (c) transgenic mouse technology has provided the foundation for these and future studies in this area. |
