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Protein Coding Gene : Supt6 SPT6, histone chaperone and transcription elongation factor

Primary Identifier  MGI:107726 Organism  mouse, laboratory
Chromosome  11 NCBI Gene Number  20926
Mgi Type  protein coding gene
description  FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.1.0)

Predicted to enable histone binding activity and nucleosome binding activity. Involved in several processes, including regulation of mRNA export from nucleus; regulation of nucleobase-containing compound metabolic process; and transcription elongation-coupled chromatin remodeling. Acts upstream of or within blastocyst formation. Predicted to be located in nucleus. Predicted to be part of transcription elongation factor complex. Is expressed in several structures, including brain; early conceptus; genitourinary system; retina; and spleen. Orthologous to human SUPT6H (SPT6 homolog, histone chaperone and transcription elongation factor).
PHENOTYPE: Mice homozygous for a knock-out allele exhibit lethality during pre-implantation development. [provided by MGI curators]
  • synonyms:
  • Supt6,
  • RIKEN cDNA 5131400N11 gene,
  • SPT6, histone chaperone and transcription elongation factor,
  • 5131400N11Rik,
  • MGD-MRK-36302,
  • suppressor of Ty 6 homolog (S. cerevisiae),
  • expressed sequence AI132449,
  • Supt6h,
  • AI132449,
  • MGI:2144073,
  • SPT6,
  • mKIAA0162,
  • MGI:1922980

Features --> Cross References

Genome

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0 Canonical

0 CDSs

0 Exons

0 Genomic Clusters

2 Involved In Mutations

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0 Transcripts

0 Transgenic Expressors

0 UTRs

Canonical gene --> CDSs in specific strains.

Canonical gene --> Exons in specific strains

Canonical gene --> Strain-specific IDs, biotypes, and locations

Canonical gene --> Transcripts in specific strains.

Features --> Overlapping features

Proteins

Gene --> Proteins

Function

Mouse features --> Functions (GO terms)

Homology

Genes --> Homologs

Interactions

5 Pathways

0 Targeted By

Gene --> Protein-Protein Interactions

Expression

Gene --> Expression annotations

Phenotype

Genes/Features --> Phenotypes (MP terms)

Disease

Mouse features --> Human diseases

Literature

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