Primary Identifier | MGI:1926877 | Allele Type | Targeted |
Attribute String | Modified isoform(s) | Gene | Cdkn2a |
Inheritance Mode | Recessive | Transmission | Germline |
Strain of Origin | 129X1/SvJ | Is Recombinase | false |
Is Wild Type | false |
molecularNote | Replacement of exon 1 beta of the Cdkn2a gene, encoding the translation start site for alternative splice transcript p19ARF, with a neomycin cassette. Note that expression of alternative splice transcript p16Ink4a, transcribed from exon 1 alpha, is not affected by this mutation. |