| Primary Identifier | MGI:102849 | Organism | mouse, laboratory |
| Chromosome | 8 | NCBI Gene Number | 16621 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.1.0) Predicted to enable serine-type endopeptidase activity. Predicted to be involved in plasminogen activation and positive regulation of fibrinolysis. Predicted to act upstream of or within several processes, including blood coagulation; fibrinolysis; and proteolysis. Predicted to be located in extracellular space. Is expressed in diencephalon roof plate; liver; liver left lobe; liver right lobe; and olfactory epithelium. Human ortholog(s) of this gene implicated in lupus nephritis and systemic lupus erythematosus. Orthologous to human KLKB1 (kallikrein B1). PHENOTYPE: Homozygous inactivation of this gene leads to reduced hematoma expansion in streptozotocin-induced diabetic mice subjected to autologous blood injection, and prolonged activated partial thromboplastin time. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
