| First Author | Mellor A | Year | 1999 |
| Journal | J Reprod Immunol | Volume | 43 |
| Issue | 2 | Pages | 253-61 |
| PubMed ID | 10479061 | Mgi Jnum | J:56914 |
| Mgi Id | MGI:1342892 | Doi | 10.1016/s0165-0378(99)00027-3 |
| Citation | Mellor A, et al. (1999) HLA-G transgenic mice. J Reprod Immunol 43(2):253-61 |
| abstractText | We have generated a number of transgenic mice using DNA segments derived from the HLA-G gene. Using these mice we have examined the pattern of expression dictated by HLA-G promoter elements in mice and shown that HLA-G functions both as a restriction element and a transplantation antigen recognized by murine T cells. In addition, we have shown that trophoblast cells expressing H-2Kb under the control of HLA-G promoter elements affect maternal T cell phenotype and responsiveness during pregnancy. Using these same HLA-G/H-2Kb transgenic mice we have shown that trophoblast cells, expressing an inducible enzyme that degrades tryptophan, protects allogeneic conceptus expressing paternally-inherited transgenes from attack by maternal T cells that leads to fetal rejection. |
