| First Author | Srivatsan S | Year | 2005 |
| Journal | J Immunol | Volume | 175 |
| Issue | 12 | Pages | 7805-9 |
| PubMed ID | 16339515 | Mgi Jnum | J:122222 |
| Mgi Id | MGI:3713603 | Doi | 10.4049/jimmunol.175.12.7805 |
| Citation | Srivatsan S, et al. (2005) Cutting edge: Foxj1 protects against autoimmunity and inhibits thymocyte egress. J Immunol 175(12):7805-9 |
| abstractText | Previous studies suggest that the forkhead transcription factor Foxj1 inhibits spontaneous autoimmunity in part by antagonizing NF-kappaB activation. To test this hypothesis, we ectopically expressed Foxj1 in the T cells of lupus-prone MRL/lpr mice by backcrossing a CD2-Foxj1 transgene against the MRL/lpr background. Strikingly, CD2-Foxj1-MRL/lpr animals showed a significant reduction in lymphadenopathy, pathogenic autoantibodies, and end-organ disease-but surprisingly, reversion of autoimmunity was not attributable to modulation of NF-kappaB. Instead, CD2-Foxj1 transgenic mice exhibited a peripheral T cell lymphopenia, associated with an accumulation of mature single-positive thymocytes. Transgenic thymocytes demonstrated unimpaired lymphoid organ entry in adoptive transfer studies but demonstrated impaired thymic exodus in response to CCL19, apparently independent of CCR7, S1P1, and NF-kappaB. These findings confirm the importance of Foxj1 in the regulation of T cell tolerance but furthermore suggest a novel and specific role for Foxj1 in regulating thymic egress. |
