| Type | disruption phenotype | Description | Mice survive to adulthood and do not display detectable physical abnormality (PubMed:20733033). However, mice were born at a rate lower than predicted by the Mendelian ratio and display defects in innate immune response (PubMed:20733033). Impaired formation of neutrophil extracellular traps (NETs) (PubMed:20733033, PubMed:32528174). Mice are more susceptible to bacterial infection: neutrophils cannot form NETs after stimulation with chemokines or incubation with bacteria, and are deficient in bacterial killing by NETs (PubMed:20733033). Less than 10% of deficient mice produce a thrombus 48 hours after inferior vena cava stenosis whereas 90% of wild-type mice do (PubMed:23650392). |
