| First Author | Zhang XH | Year | 2013 |
| Journal | Mol Cell Endocrinol | Volume | 381 |
| Issue | 1-2 | Pages | 272-9 |
| PubMed ID | 23994020 | Mgi Jnum | J:211370 |
| Mgi Id | MGI:5574556 | Doi | 10.1016/j.mce.2013.08.011 |
| Citation | Zhang XH, et al. (2013) Heparin-binding epidermal growth factor-like growth factor (HB-EGF) induction on Snail expression during mouse decidualization. Mol Cell Endocrinol 381(1-2):272-9 |
| abstractText | Embryo implantation requires a precise synchronism between the receptive uterus and activated blastocyst and is regulated by complicated molecular networks. Although many implantation-related genes have been identified, the crosstalk among them is still unknown. Snail, a transcription repressor, plays a central role during epithelial-mesenchymal transition. Our previous study showed that Snail is highly expressed at implantation site in mouse uterus. This study was to examine how Snail is related with other implantation-related genes in mice. Uterine stromal cells were isolated from mouse uteri on day 4 of pregnancy and treated with HB-EGF. Snail was induced significantly by HB-EGF. By using specific inhibitors and siRNA, we demonstrated that HB-EGF induction on Snail expression is dependent on the EGFR-ERK-Stat3 pathway. Cox-2 was regulated by Snail. The current findings demonstrate that Snail can relate with HB-EGF, Stat3 and Cox-2 and may play a role during mouse embryo implantation and decidualization. |
