| First Author | Gilfillan S | Year | 2002 |
| Journal | Nat Immunol | Volume | 3 |
| Issue | 12 | Pages | 1150-5 |
| PubMed ID | 12426564 | Mgi Jnum | J:80426 |
| Mgi Id | MGI:2445858 | Doi | 10.1038/ni857 |
| Citation | Gilfillan S, et al. (2002) NKG2D recruits two distinct adapters to trigger NK cell activation and costimulation. Nat Immunol 3(12):1150-5 |
| abstractText | NKG2D is a receptor on natural killer (NK) cells and cytotoxic T lymphocytes that binds major histocompatibility complex (MHC) class I-like ligands expressed primarily on virally infected and neoplastic cells. In vitro studies indicate that NKG2D provides costimulation through an associated adapter, DAP10, which recruits phosphatidylinositol-3 kinase. Here we show that in DAP10-deficient mice, CD8(+) T cells lack NKG2D expression and are incapable of mounting tumor-specific responses. However, DAP10-deficient NK cells express a functional NKG2D receptor due to the association of NKG2D with another adapter molecule, DAP12 (also known as KARAP), which recruits protein tyrosine kinases. Thus, NKG2D is a versatile receptor that, depending on the availability of adapter partners, mediates costimulation in T cells and/or activation in NK cells. |
