| Primary Identifier | IPR016729 | Type | Family |
| Short Name | FADD |
| description | This entry represents the Fas-associated death domain protein FADD. This is an apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate, called the death-inducing signalling complex (DISC), performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. For further information see [, , , , ]. |
