| Primary Identifier | MGI:5431522 | Allele Type | Transgenic |
| Attribute String | Inserted expressed sequence | Gene | Tg(HLA-DRA,HLA-DRB1*0405)1Jic |
| Strain of Origin | (NOD/Shi x NOD.Cg-Prkdc<scid> Il2rg<tm1Sug>/Jic)F1 | Is Recombinase | false |
| Is Wild Type | false |
| molecularNote | Mouse fertilized oocytes were microinjected with transgene constructs in which the human MHC class II genes HLA-DRA and HLA-DRB1*0405, whose protein products together constitute HLA-DR4, reside downstream of the promoter region (nt -2172 to +12) of the mouse MHC class II Ea gene. The HLA coding sequence, in each case, is inserted into a ~1200 bp segment of the rabbit beta-globin gene which provides an intron, 3'-untranslated region (3'-UTR) and polyadenylation signal. |
