| Primary Identifier | MGI:3639880 | Allele Type | Spontaneous |
| Gene | Irs1 | Inheritance Mode | Semidominant |
| Strain of Origin | C3.SW-H2<b>/SnJ | Is Recombinase | false |
| Is Wild Type | false |
| molecularNote | This spontaneous mutation has a deletion of one adenine in exon 1 at position 1559 which results in a frameshift leading to a premature stop codon predicted to yield only a 211 amino acid protein rather than the full-length 1233 amino acids. Western blot analysis using a C-terminus specific antibody failed to detect a protein product in liver extracts of homozygotes. |
