| First Author | Inoue E | Year | 2004 |
| Journal | Biosci Biotechnol Biochem | Volume | 68 |
| Issue | 10 | Pages | 2209-11 |
| PubMed ID | 15502373 | Mgi Jnum | J:102110 |
| Mgi Id | MGI:3606820 | Doi | 10.1271/bbb.68.2209 |
| Citation | Inoue E, et al. (2004) Transcriptional coactivator p300/CBP-associated factor and p300/CBP-associated factor type B are required for normal estrogen response of the mouse uterus. Biosci Biotechnol Biochem 68(10):2209-11 |
| abstractText | Mice with targeted gene disruption of one of the estrogen receptor coactivators, p300/CBP-associated factor (PCAF), and its counterpart, PCAF-B, were used to investigate the possible involvement of PCAF and PCAF-B in estrogen receptor-mediated actions in vivo. Among ovariectomized mice that were treated with estrogen, PCAF and PCAF/PCAF-B knockouts showed abnormal growth of the uterus compared with the wild type. The level of c-fos gene expression in the uterus was not induced by estrogen in the knockouts. These observations suggest that PCAF and PCAF-B are required for estrogen-dependent normal growth of the uterus via estrogen receptor-mediated transcriptional regulations. |
