| First Author | Summers deLuca L | Year | 2011 |
| Journal | Proc Natl Acad Sci U S A | Volume | 108 |
| Issue | 5 | Pages | 2046-51 |
| PubMed ID | 21245292 | Mgi Jnum | J:169124 |
| Mgi Id | MGI:4939877 | Doi | 10.1073/pnas.1014188108 |
| Citation | Summers deLuca L, et al. (2011) LT{beta}R signaling in dendritic cells induces a type I IFN response that is required for optimal clonal expansion of CD8+ T cells. Proc Natl Acad Sci U S A 108(5):2046-51 |
| abstractText | During an immune response, antigen-bearing dendritic cells (DCs) migrate to the local draining lymph node and present antigen to CD4(+) helper T cells. Antigen-activated CD4(+) T cells then up-regulate TNF superfamily members including CD40 ligand and lymphotoxin (LT)alphabeta. Although it is well-accepted that CD40 stimulation on DCs is required for DC licensing and cross-priming of CD8(+) T-cell responses, it is likely that other signals are integrated into a comprehensive DC activation program. Here we show that a cognate interaction between LTalphabeta on CD4(+) helper T cells and LTbeta receptor on DCs results in unique signals that are necessary for optimal CD8(+) T-cell expansion via a type I IFN-dependent mechanism. In contrast, CD40 signaling appears to be more critical for CD8(+) T-cell IFNgamma production. Therefore, different TNF family members provide integrative signals that shape the licensing potential of antigen-presenting DCs. |
