| First Author | McNerney ME | Year | 2005 |
| Journal | Blood | Volume | 106 |
| Issue | 4 | Pages | 1337-40 |
| PubMed ID | 15870174 | Mgi Jnum | J:117290 |
| Mgi Id | MGI:3695963 | Doi | 10.1182/blood-2005-01-0357 |
| Citation | McNerney ME, et al. (2005) 2B4 (CD244)-CD48 interactions provide a novel MHC class I-independent system for NK-cell self-tolerance in mice. Blood 106(4):1337-40 |
| abstractText | Natural killer (NK) cells must be able to eliminate infected and transformed cells while remaining tolerant of normal cells. NK-cell self-tolerance is thought to be maintained by self-major histocompatibility complex (MHC) class I recognition; however, there are examples where NK cells are not regulated by MHC class I and yet remain self-tolerant. Here, we show that 2B4 (CD244) and CD48 represent a second system for murine NK-cell self-recognition. 2B4 and MHC class I receptors act nonredundantly to inhibit NK lysis of syngeneic tumor cells. NK cells from beta2 microglobulin (beta2m)-deficient mice and NK cells that lack expression of self-MHC-binding inhibitory receptors are inhibited by 2B4. Moreover, we provide the first in vivo evidence for MHC-independent NK self-recognition in a bone marrow rejection assay. These data suggest that NK-cell self-tolerance can be mediated by molecules other than MHC. |
