| First Author | Hatakeyama S | Year | 1998 |
| Journal | Int Immunol | Volume | 10 |
| Issue | 5 | Pages | 631-7 |
| PubMed ID | 9645611 | Mgi Jnum | J:47747 |
| Mgi Id | MGI:1205987 | Doi | 10.1093/intimm/10.5.631 |
| Citation | Hatakeyama S, et al. (1998) Multiple gene duplication and expression of mouse bcl-2-related genes, A1. Int Immunol 10(5):631-7 |
| abstractText | Here we report the genomic cloning and characterization of the murine A1 genes, which belong to the bcl-2 gene family. Southern analysis indicated the existence of at least four A1 genes in the murine genome and four different A1 genes, designated A1-a, -b, -c and -d, were cloned from the murine genomic library. The A1-a, -b and -d genes consisted of two exons, whereas the A1-c gene contained 1 bp insertion in the coding region which may result in an aberrant and truncated protein by frame-shift. With the exception of A1-c, the coding regions among A1 genes are highly conserved at >97% at the nucleotide level and at >96% at the amino acid level. A1-a, -b and -d genes appeared to be expressed specifically in organs containing many neutrophils. In neutrophils, A1-a, -b and -d transcripts were detected at a comparable level. Our data suggest that the multiple A1 genes in mice were generated by gene duplication and each of them may function as anti-apoptotic molecules in neutrophils. |
