| Primary Identifier | IPR037399 | Type | Family |
| Short Name | PTGR2 |
| description | Prostaglandins and related eicosanoids are metabolized by the oxidation of the 15(S)-hydroxyl group of the NAD+-dependent (type I 15-PGDH) 15-prostaglandin dehydrogenase (15-PGDH) followed by reduction by NADPH/NADH-dependent (type II 15-PGDH) delta-13 15-prostaglandin reductase (13-PGR) to 15-keto-13,14-dihydroprostaglandins []. Prostaglandin reductase 2 (also known as 15-oxoprostaglandin 13-reductase, 13-PGR) is a bifunctional enzyme, since it also has leukotriene B(4) 12-hydroxydehydrogenase activity []. It belongs to the MDR/zinc-dependent alcohol dehydrogenase-like family. The MDR/zinc-dependent alcohol dehydrogenase-like family, which contains the zinc-dependent alcohol dehydrogenase (ADH-Zn) and related proteins, is a diverse group of proteins related to the first identified member, class I mammalian ADH []. MDRs display a broad range of activities and are distinguished from the smaller short chain dehydrogenases (~ 250 amino acids vs. the ~ 350 amino acids of the MDR) []. The MDR proteins have 2 domains: a C-terminal NAD(P) binding-Rossmann fold domain of a beta-alpha form and an N-terminal catalytic domain with distant homology to GroES []. |
