| First Author | Aasheim HC | Year | 1998 |
| Journal | Biochem Biophys Res Commun | Volume | 252 |
| Issue | 2 | Pages | 378-82 |
| PubMed ID | 9826538 | Mgi Jnum | J:51075 |
| Mgi Id | MGI:1314561 | Doi | 10.1006/bbrc.1998.9618 |
| Citation | Aasheim HC, et al. (1998) Cloning, chromosal mapping, and tissue expression of the gene encoding the human Eph-family kinase ligand ephrin-A2. Biochem Biophys Res Commun 252(2):378-82 |
| abstractText | The Eph-related receptor tyrosine kinases constitute a large family of receptors with most members displaying specific expression patterns in the developing embryo. Ligands for Eph receptor tyrosine kinases, recently renamed ephrins, comprise a family of at least 8 membrane-bound members that display promiscuous binding to Eph receptors. Here we report the characterization of a human cDNA clone with high homology to the gene encoding the murine ephrin-A2 ligand. The human gene encodes a single 2.4-kb mRNA with a restricted and developmentally-regulated tissue distribution pattern. In the fetus, ephrin-A2 mRNA is expressed in brain and intestine, whereas in the adult, high levels of ephrin-A2 mRNA are detectable in lung and intestine. Using PCR-based screening of genomic DNA from human x rodent hybrid cell lines, the gene encoding ephrin-A2 (EFNA2) was assigned to chromosome 19. Fluorescence in situ hybridization to metaphase chromosome preparations refined this localization to band p13.3. Copyright 1998 Academic Press. |
