| Primary Identifier | IPR028761 | Type | Family |
| Short Name | Dab |
| description | This entry represents the protein disabled (DAB) and related proteins. It includes DAB from Drosophila melanogaster and its mammlian homologues, DAB1 and DAB2 (also known as DOC1 and DOC2). This group of proteins are adapter proteins that play roles in development. In Drosophila melanogaster, DAB acts as an adapter protein for SH2-domain containing proteins in the sevenless (sev) signalling pathway []. Together with Abl, it is involved in embryonic neural development []. In mammals, DAB1 is implicated in neuronal development []. In humans, DAB2 is an adapter protein that functions as clathrin-associated sorting protein (CLASP) required for clathrin-mediated endocytosis of selected cargo proteins []. It is involved in several signalling pathways and plays an important part in cell growth and development [, , ]. |
