| First Author | Muhlethaler-Mottet A | Year | 1997 |
| Journal | EMBO J | Volume | 16 |
| Issue | 10 | Pages | 2851-60 |
| PubMed ID | 9184229 | Mgi Jnum | J:40766 |
| Mgi Id | MGI:892132 | Doi | 10.1093/emboj/16.10.2851 |
| Citation | Muhlethaler-Mottet A, et al. (1997) Expression of MHC class II molecules in different cellular and functional compartments is controlled by differential usage of multiple promoters of the transactivator CIITA. EMBO J 16(10):2851-60 |
| abstractText | The highly complex pattern of expression of major histocompatibility complex class II (MHC-II) molecules determines both the immune repertoire during development and subsequently the triggering and the control of immune responses. These distinct functions result from cell type-restricted expression, developmental control and either constitutive or inducible expression of MHC-II genes. Yet, in these various situations, MHC-II gene expression is always under the control of a unique transactivator, CIITA. Here we show that the CIITA gene is controlled by several distinct promoters, two of which direct specific constitutive expression in dendritic cells and B lymphocytes respectively, while another mediates gamma-interferon-induced expression. Thus the cellular, temporal and functional diversity of MHC-II expression is ultimately controlled by differential activation of different promoters of a single transactivator gene. This provides novel experimental tools to dissect compartment-specific gain or loss of MHC-II function in vivo. |
