| First Author | Aida K | Year | 1997 |
| Journal | Horm Metab Res | Volume | 29 |
| Issue | 12 | Pages | 646-9 |
| PubMed ID | 9497905 | Mgi Jnum | J:46123 |
| Mgi Id | MGI:1197159 | Doi | 10.1055/s-2007-978982 |
| Citation | Aida K, et al. (1997) Mouse glycine N-methyltransferase is sexually dimorphic and regulated by growth hormone. Horm Metab Res 29(12):646-9 |
| abstractText | The secretion pattern of putuitary growth hormone (GH) in rodents is sexually dimorphic and regulates the expression of some hepatic genes. We report cloning of mouse glycine N-methyltransferase (GNMT) cDNA. The mouse GNMT mRNA is expressed at much lower levels in male than in female livers. Hypophysectomy in male mice resulted in as a high level of the expression as in female mice. Treatment with GH of hypophysectomized male mice twice a day for 5 days decreased the expression. These results indicate that the sex difference of the mouse GNMT expression is regulated by GH secretion patterns. |
