| First Author | Bernardino L | Year | 2012 |
| Journal | Stem Cells | Volume | 30 |
| Issue | 4 | Pages | 773-84 |
| PubMed ID | 22893458 | Mgi Jnum | J:192780 |
| Mgi Id | MGI:5466470 | Doi | 10.1002/stem.1042 |
| Citation | Bernardino L, et al. (2012) Histamine stimulates neurogenesis in the rodent subventricular zone. Stem Cells 30(4):773-84 |
| abstractText | Neural stem/progenitor cells present in the subventricular zone (SVZ) are a potential source of repairing cells after injury. Therefore, the identification of novel players that modulate neural stem cells differentiation can have a huge impact in stem cell-based therapies. Herein, we describe a unique role of histamine in inducing functional neuronal differentiation from cultured mouse SVZ stem/progenitor cells. This proneurogenic effect depends on histamine 1 receptor activation and involves epigenetic modifications and increased expression of Mash1, Dlx2, and Ngn1 genes. Biocompatible poly (lactic-co-glycolic acid) microparticles, engineered to release histamine in a controlled and prolonged manner, also triggered robust neuronal differentiation in vitro. Preconditioning with histamine-loaded microparticles facilitated neuronal differentiation of SVZ-GFP cells grafted in hippocampal slices and in in vivo rodent brain. We propose that neuronal commitment triggered by histamine per se or released from biomaterial-derived vehicles may represent a new tool for brain repair strategies. |
