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Protein Coding Gene : Git2 GIT ArfGAP 2
Primary Identifier  MGI:1347053 Organism  mouse, laboratory
Chromosome  5 NCBI Gene Number  26431
Mgi Type  protein coding gene
description  FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.1.0)

Predicted to enable GTPase activator activity and small GTPase binding activity. Involved in presynaptic modulation of chemical synaptic transmission and regulation of synaptic vesicle exocytosis. Acts upstream of or within behavioral response to pain. Is active in calyx of Held. Is expressed in genitourinary system. Orthologous to human GIT2 (GIT ArfGAP 2).
PHENOTYPE: Mice homozygous for a null allele show frequent splenomegaly, extramedullary hematopoiesis, impaired neutrophil chemotaxis, misoriented hyperproduction of superoxide anions and increased susceptibility to fungal infection. Homozygotes for a gene trap allele have reduced marginal zone B cell numbers. [provided by MGI curators]
  • synonyms:
  • MGI:1925227,
  • GIT ArfGAP 2,
  • RIKEN cDNA 5830420E16 gene,
  • MGI:2443204,
  • 9630056M03Rik,
  • RIKEN cDNA 1500036H07 gene,
  • RIKEN cDNA 9630056M03 gene,
  • RIKEN cDNA B230104M05 gene,
  • Git2,
  • MGI:1919676,
  • ARF GTPase activating protein 2,
  • 5830420E16Rik,
  • MGI:1923277,
  • 1500036H07Rik,
  • B230104M05Rik,
  • Cat-2,
  • Cool associated tyrosine phosphorylated-2
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Features --> Cross References

Genome

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2 Involved In Mutations

Trail: ProteinCodingGene

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0 Transgenic Expressors

0 UTRs

Canonical gene --> CDSs in specific strains.

Canonical gene --> Exons in specific strains

Canonical gene --> Strain-specific IDs, biotypes, and locations

Canonical gene --> Transcripts in specific strains.

Features --> Overlapping features

Proteins

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Function

Mouse features --> Functions (GO terms)

Homology

Genes --> Homologs

Interactions

10 Pathways

Trail: ProteinCodingGene

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Gene --> Protein-Protein Interactions

Expression

Gene --> Expression annotations

Phenotype

Genes/Features --> Phenotypes (MP terms)

Disease

Mouse features --> Human diseases

Literature

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