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Comment :

Type  MGI:General Description  at 18 months, muscle fibers exhibit an increase in the number and size of mitochondria compared to in wild-type mice severely affected muscle fibers exhibit large mitochondria with concentric cristae and electron-dense inclusions unlike in wild-type mice at 18 months, mice exhibit COX-SDH+, markers of decreased respiratory function and increased proliferation, muscles cells unlike wild-type mice