| First Author | Bruhns P | Year | 2003 |
| Journal | Immunity | Volume | 18 |
| Issue | 4 | Pages | 573-81 |
| PubMed ID | 12705859 | Mgi Jnum | J:83013 |
| Mgi Id | MGI:2656457 | Doi | 10.1016/s1074-7613(03)00080-3 |
| Citation | Bruhns P, et al. (2003) Colony-stimulating factor-1-dependent macrophages are responsible for IVIG protection in antibody-induced autoimmune disease. Immunity 18(4):573-81 |
| abstractText | The ability of IVIG to induce expression of Fc gamma RIIB and thereby prevent antibody-induced inflammation has been used as a probe to dissect the effector cell components in the KRNxNOD (K/BxN) arthritis model. IVIG protection resulted from the induction of Fc gamma RIIB on infiltrating macrophages but not neutrophils, indicating a critical role for macrophage activation in this disease model. Disease induction but not IVIG protection was observed in CSF-1-deficient mice (op/op) in K/BxN arthritis, thus defining different macrophage subsets in these processes. These results suggest a two-step model for IVIG protection in which CSF-1-dependent macrophages act as innate 'sensors' for the Fc fragment of IVIG, leading to the induction of Fc gamma RIIB on CSF-1-independent 'effector' macrophages thereby raising the threshold required for Fc gamma RIII activation and preventing autoantibody-triggered inflammation. |
