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Protein Coding Gene : P2rx6 purinergic receptor P2X, ligand-gated ion channel, 6
Primary Identifier  MGI:1337113 Organism  mouse, laboratory
Chromosome  16 NCBI Gene Number  18440
Mgi Type  protein coding gene
description  FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.1.0)

Predicted to enable extracellularly ATP-gated monoatomic cation channel activity. Predicted to be involved in calcium ion transmembrane transport. Predicted to act upstream of or within excitatory postsynaptic potential and monoatomic cation transmembrane transport. Predicted to be located in cytoplasm; dendritic spine; and neuronal cell body. Predicted to be part of receptor complex. Predicted to be active in glutamatergic synapse; parallel fiber to Purkinje cell synapse; and postsynaptic specialization membrane. Is expressed in central nervous system; heart; parathyroid gland; reproductive system; and respiratory system. Orthologous to human P2RX6 (purinergic receptor P2X 6).
PHENOTYPE: Homozygous mutant mice exhibit a significant increase in thermal response latency during hot plate testing, and are resistant to metrazol-induced seizures. [provided by MGI curators]
  • synonyms:
  • purinergic receptor P2X, ligand-gated ion channel, 6,
  • purinergic receptor P2X-like 1, orphan receptor,
  • P2xm,
  • P2rxl1,
  • P2rx6
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1 Involved In Mutations

Trail: ProteinCodingGene

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Canonical gene --> CDSs in specific strains.

Canonical gene --> Exons in specific strains

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Canonical gene --> Transcripts in specific strains.

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Proteins

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Function

Mouse features --> Functions (GO terms)

Homology

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Interactions

4 Pathways

Trail: ProteinCodingGene

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Gene --> Protein-Protein Interactions

Expression

Gene --> Expression annotations

Phenotype

Genes/Features --> Phenotypes (MP terms)

Disease

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