Primary Identifier | MGI:7258412 | Allele Type | Endonuclease-mediated |
Attribute String | Not Specified | Gene | Ripk1 |
Is Recombinase | false | Is Wild Type | false |
molecularNote | Using an sgRNA (targeting CCCGAAGCCTCCGCTGTCT) and an ssODN template with CRISPR/Cas9 technology, a 6 bp sequence was deleted (c.81_86delCTTCGG), resulting in the deletion of two highly conserved amino acids, F28 and G29, from the P-loop of the N-terminal kinase domain of the encoded protein. |