| Primary Identifier | MGI:95559 | Organism | mouse, laboratory |
| Chromosome | 5 | NCBI Gene Number | 14255 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.0.0) Enables several functions, including phosphatidylinositol 3-kinase binding activity; protein tyrosine kinase activity; and ubiquitin protein ligase binding activity. Involved in several processes, including common myeloid progenitor cell proliferation; hemopoiesis; and lymphocyte proliferation. Acts upstream of or within several processes, including dendritic cell homeostasis; hematopoietic or lymphoid organ development; and regulation of cytokine production. Located in external side of plasma membrane. Is expressed in several structures, including aorta-gonad-mesonephros; brain; immune system; retina; and spinal cord. Used to study acute myeloid leukemia and juvenile myelomonocytic leukemia. Human ortholog(s) of this gene implicated in gastrointestinal system cancer (multiple); leukemia (multiple); and prostate cancer. Orthologous to human FLT3 (fms related receptor tyrosine kinase 3). PHENOTYPE: Mice functionally null for this gene display abnormal lymphopoiesis. Homozygous ENU mutant mice are sensitive to infection by mouse cytomegalovirus. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
