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Protein Coding Gene : Sirt5 sirtuin 5

Primary Identifier  MGI:1915596 Organism  mouse, laboratory
Chromosome  13 NCBI Gene Number  68346
Mgi Type  protein coding gene
description  FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.1.0)

Enables protein-glutaryllysine deglutarylase activity; protein-malonyllysine demalonylase activity; and protein-succinyllysine desuccinylase activity. Involved in regulation of ketone biosynthetic process. Acts upstream of or within response to ischemia. Located in cytosol and mitochondrial inner membrane. Is expressed in several structures, including 1st branchial arch maxillary component; heart; oocyte; palatal shelf; and sensory organ. Orthologous to human SIRT5 (sirtuin 5).
PHENOTYPE: Mice homozygous for a knock-out allele are viable, fertile and grossly healthy and do not exhibit globally increased mitochondrial protein acetylation levels relative to wild-type controls. [provided by MGI curators]
  • synonyms:
  • Sirt5,
  • sirtuin 5,
  • MGI:2145383,
  • AV001953,
  • 0610012J09Rik,
  • 1500032M05Rik,
  • RIKEN cDNA 0610012J09 gene,
  • RIKEN cDNA 1500032M05 gene,
  • expressed sequence AV001953,
  • MGI:1917010

Features --> Cross References

Genome

Sequence Feature Displayer

JG Browse Displayer

0 Canonical

0 CDSs

0 Exons

0 Genomic Clusters

1 Involved In Mutations

0 Strain

0 Transcripts

0 Transgenic Expressors

0 UTRs

Canonical gene --> CDSs in specific strains.

Canonical gene --> Exons in specific strains

Canonical gene --> Strain-specific IDs, biotypes, and locations

Canonical gene --> Transcripts in specific strains.

Features --> Overlapping features

Proteins

Gene --> Proteins

Function

Mouse features --> Functions (GO terms)

Homology

Genes --> Homologs

Interactions

3 Pathways

0 Targeted By

Gene --> Protein-Protein Interactions

Expression

Gene --> Expression annotations

Phenotype

Genes/Features --> Phenotypes (MP terms)

Disease

Mouse features --> Human diseases

Literature

Mouse features --> Publications

 

Other

0 Driver For