Primary Identifier | MGI:108068 | Organism | mouse, laboratory |
Chromosome | 5 | NCBI Gene Number | 14825 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.1.0) Predicted to enable CXCR chemokine receptor binding activity and chemokine activity. Involved in several processes, including positive regulation of hematopoietic stem cell proliferation; positive regulation of neutrophil mediated killing of fungus; and positive regulation of superoxide anion generation. Located in extracellular space. Is expressed in several structures, including arterial system; liver; nervous system; retina; and small intestine. Orthologous to human CXCL1 (C-X-C motif chemokine ligand 1) and CXCL2 (C-X-C motif chemokine ligand 2). PHENOTYPE: Targeted mutations in this gene when combine with targeted mutation of Ldlr decreases susceptibility to atherosclerotic lesions. [provided by MGI curators] |