| First Author | Freimert C | Year | 1991 |
| Journal | Gene | Volume | 103 |
| Issue | 2 | Pages | 259-61 |
| PubMed ID | 1889751 | Mgi Jnum | J:15355 |
| Mgi Id | MGI:59845 | Doi | 10.1016/0378-1119(91)90283-h |
| Citation | Freimert C, et al. (1991) Isolation of a cathepsin B-encoding cDNA from murine osteogenic cells. Gene 103(2):259-61 |
| abstractText | Cathepsin B-encoding cDNA (CTSB) clones have been isolated from a lambda gt10 library of a murine osteosarcoma by differential screening during a search for genes which are typically expressed during osteogenic differentiation in mouse mandibular condyles in vitro. Sequencing of the CTSB 3' end revealed that the isolated sequence contained an 825-bp 3'-noncoding region, the polyadenylation signal and the poly(A) tail. The enhanced CTSB expression during the early stages of the enchondral ossification-like process in mandibular condyles in vitro suggests that CTSB participates in the degradation of cartilage matrix prior to the synthesis of bone matrix proteins. |
