| First Author | Thiault N | Year | 2015 |
| Journal | Nat Immunol | Volume | 16 |
| Issue | 6 | Pages | 628-34 |
| PubMed ID | 25939024 | Mgi Jnum | J:232834 |
| Mgi Id | MGI:5780277 | Doi | 10.1038/ni.3150 |
| Citation | Thiault N, et al. (2015) Peripheral regulatory T lymphocytes recirculating to the thymus suppress the development of their precursors. Nat Immunol 16(6):628-34 |
| abstractText | Most T lymphocytes, including regulatory T cells (Treg cells), differentiate in the thymus. The age-dependent involution of this organ leads to decreasing production of T cells. Here we found that the output of new Treg cells from the thymus decreased substantially more than that of conventional T cells. Peripheral mouse and human Treg cells recirculated back to the thymus, where they constituted a large proportion of the pool of Treg cells and displayed an activated and differentiated phenotype. In the thymus, the recirculating cells exerted their regulatory function by inhibiting interleukin 2 (IL-2)-dependent de novo differentiation of Treg cells. Thus, Treg cell development is controlled by a negative feedback loop in which mature progeny cells return to the thymus and restrain development of precursors of Treg cells. |
