| First Author | de Hostos EL | Year | 1999 |
| Journal | Trends Cell Biol | Volume | 9 |
| Issue | 9 | Pages | 345-50 |
| PubMed ID | 10461187 | Mgi Jnum | J:56832 |
| Mgi Id | MGI:1342784 | Doi | 10.1016/s0962-8924(99)01620-7 |
| Citation | de Hostos EL (1999) The coronin family of actin-associated proteins. Trends Cell Biol 9(9):345-50 |
| abstractText | Coronin was first isolated from Dictyostelium, but similar proteins have been identified in many species and individual cell types. The coronin-like protein in yeast promotes actin polymerization and also interacts with microtubules. Dictyostelium mutants lacking coronin are impaired in cytokinesis and all actin-mediated processes. Analysis of coronin-GFP (green-fluorescent protein) fusions and knockout mutants shows that coronin participates in the remodelling of the cortical actin cytoskeleton that is responsible for phagocytosis and macropinocytosis. Likewise, in mammalian neutrophils, a coronin-like protein is also associated with the phagocytic apparatus. The diversity of function in this family of actin-associated proteins is just beginning to be explored. |
