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Protein Coding Gene : Tnik TRAF2 and NCK interacting kinase
Primary Identifier  MGI:1916264 Organism  mouse, laboratory
Chromosome  3 NCBI Gene Number  665113
Mgi Type  protein coding gene
description  FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.1.0)

Predicted to enable protein serine/threonine kinase activity. Involved in regulation of neurotransmitter receptor localization to postsynaptic specialization membrane. Is active in glutamatergic synapse. Human ortholog(s) of this gene implicated in autosomal recessive intellectual developmental disorder 54. Orthologous to human TNIK (TRAF2 and NCK interacting kinase).
PHENOTYPE: Mice homozygous for a knock-out allele exhibit impaired postsynaptic signaling and cognitive function. [provided by MGI curators]
  • synonyms:
  • C530008O15Rik,
  • MGI:2441673,
  • expressed sequence AI451411,
  • Tnik,
  • TRAF2 and NCK interacting kinase,
  • 4831440I19Rik,
  • RIKEN cDNA C630040K21 gene,
  • C630040K21Rik,
  • MGI:2139720,
  • MGI:1925958,
  • 1500031A17Rik,
  • RIKEN cDNA 4831440I19 gene,
  • RIKEN cDNA 1500031A17 gene,
  • AI451411,
  • MGI:2444917,
  • RIKEN cDNA C530008O15 gene
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