| Primary Identifier | MGI:102772 | Organism | mouse, laboratory |
| Chromosome | 3 | NCBI Gene Number | 14469 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.0.0) Predicted to enable several functions, including cytoskeletal protein binding activity; guanyl ribonucleotide binding activity; and pyrophosphatase activity. Involved in several processes, including cellular response to interferon-beta; positive regulation of innate immune response; and positive regulation of pyroptosis. Acts upstream of or within adhesion of symbiont to host; cellular response to lipopolysaccharide; and defense response to other organism. Located in cytoplasmic vesicle and symbiont-containing vacuole membrane. Is active in symbiont cell surface. Is expressed in several structures, including alimentary system; brain; cardiovascular system; genitourinary system; and sensory organ. Orthologous to several human genes including GBP2 (guanylate binding protein 2). PHENOTYPE: Homozygous inactivation of this gene leads to increased susceptibility to chronic Toxoplasma gondii infection, characterized by an increased parasite burden in the brain. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
