| First Author | Shin HH | Year | 2007 |
| Journal | FEBS Lett | Volume | 581 |
| Issue | 22 | Pages | 4355-60 |
| PubMed ID | 17716663 | Mgi Jnum | J:125180 |
| Mgi Id | MGI:3757806 | Doi | 10.1016/j.febslet.2007.08.015 |
| Citation | Shin HH, et al. (2007) Absence of 4-1BB increases cell influx into the peritoneal cavity in response to LPS stimulation by decreasing macrophage IL-10 levels. FEBS Lett 581(22):4355-60 |
| abstractText | Peritoneal injection of lipopolysaccharide (LPS) increased the influx of polymorphonuclear leukocytes and macrophages into the peritoneal cavity (PEC), with significantly higher cell numbers in the 4-1BB-deficient (KO) mice than in wild-type (WT) mice. The peritoneal macrophages of KO mice contained less IL-10 transcripts and protein than those of WT after LPS treatment, and immobilization of 4-1BB-Fc increased the level of IL-10. Injection of IL-10 resulted in lower cell numbers into the PEC of KO mice, suggesting that lower level of IL-10 is responsible for stimulated cell influx in KO mice due to lack of 4-1BB and 4-1BBL interaction. |
