| Primary Identifier | IPR040134 | Type | Family |
| Short Name | PSMD12/CSN4 |
| description | The 26S proteasome consists of a 20S proteolytic core particle (CP) and a 19S regulatory particle (RP). The RP can be further divided into two subcomplexes, the base that directly associates with the CP and a peripheral lid. The RP lid is structurally similar to the COP9 signalosome (CSN). The core CSN subunits (CSN4/5/7/6) show a remarkable one-to-one sequence correspondence with those of the RP lid (RPN5/11/9/8), suggesting a common ancestry and architecture [].This family includes the 26S Proteasome non-ATPase regulatory subunit 12 (PSMD12 or RPN5), a component of the 26S proteasome lid [], and the COP9 signalosome subunit 4 []. |
