| First Author | Sun D | Year | 2012 |
| Journal | FEBS Lett | Volume | 586 |
| Issue | 10 | Pages | 1472-9 |
| PubMed ID | 22673513 | Mgi Jnum | J:185497 |
| Mgi Id | MGI:5429083 | Doi | 10.1016/j.febslet.2012.03.068 |
| Citation | Sun D, et al. (2012) MiR-26 controls LXR-dependent cholesterol efflux by targeting ABCA1 and ARL7. FEBS Lett 586(10):1472-9 |
| abstractText | Cellular cholesterol levels are tightly regulated and represent a balance of cholesterol uptake, endogenous synthesis and efflux. Although the classic transcriptional regulations of cholesterol metabolism by liver X receptors (LXRs) have been well studied, the potential effects of LXR-responsive microRNAs (miRNAs) still need to be unveiled. Here, we describe that miR-26, an LXR-suppressed miRNA, inhibits the expression of the ATP-binding cassette transporter A1 (ABCA1) and ADP-ribosylation factor-like 7 (ARL7), two LXR target genes which play critical roles in cholesterol efflux. These findings have not only figured out an alternative mechanism for LXR regulation, but also provided a potential therapeutic target for cholesterol metabolic disorders. |
