| First Author | Lehmann CHK | Year | 2017 |
| Journal | J Exp Med | Volume | 214 |
| Issue | 5 | Pages | 1509-1528 |
| PubMed ID | 28389502 | Mgi Jnum | J:242013 |
| Mgi Id | MGI:5904203 | Doi | 10.1084/jem.20160951 |
| Citation | Lehmann CHK, et al. (2017) DC subset-specific induction of T cell responses upon antigen uptake via Fcgamma receptors in vivo. J Exp Med 214(5):1509-1528 |
| abstractText | Dendritic cells (DCs) are efficient antigen-presenting cells equipped with various cell surface receptors for the direct or indirect recognition of pathogenic microorganisms. Interestingly, not much is known about the specific expression pattern and function of the individual activating and inhibitory Fcgamma receptors (FcgammaRs) on splenic DC subsets in vivo and how they contribute to the initiation of T cell responses. By targeting antigens to select activating and the inhibitory FcgammaR in vivo, we show that antigen uptake under steady-state conditions results in a short-term expansion of antigen-specific T cells, whereas under inflammatory conditions especially, the activating FcgammaRIV is able to induce superior CD4+ and CD8+ T cell responses. Of note, this effect was independent of FcgammaR intrinsic activating signaling pathways. Moreover, despite the expression of FcgammaRIV on both conventional splenic DC subsets, the induction of CD8+ T cell responses was largely dependent on CD11c+CD8+ DCs, whereas CD11c+CD8- DCs were critical for priming CD4+ T cell responses. |
