Primary Identifier | MGI:95909 | Organism | mouse, laboratory |
Chromosome | 17 | NCBI Gene Number | 14977 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.4.0) Enables zinc ion transmembrane transporter activity. Involved in B cell differentiation; skin epidermis development; and zinc ion transmembrane transport. Predicted to be located in endoplasmic reticulum membrane and nucleoplasm. Is expressed in several structures, including adipose tissue; alimentary system; genitourinary system; immune system; and nervous system. Human ortholog(s) of this gene implicated in agammaglobulinemia 9. Orthologous to human SLC39A7 (solute carrier family 39 member 7). PHENOTYPE: Mice homozygous for a conditional allele activated in intestinal epithelial cells exhibit premature death, loss of epithelial integrity, reduced enterocyte proliferation and increased enterocyte apoptosis. [provided by MGI curators] |