| First Author | Kirschner K | Year | 2017 |
| Journal | Cell Rep | Volume | 19 |
| Issue | 8 | Pages | 1503-1511 |
| PubMed ID | 28538171 | Mgi Jnum | J:254311 |
| Mgi Id | MGI:6103530 | Doi | 10.1016/j.celrep.2017.04.074 |
| Citation | Kirschner K, et al. (2017) Proliferation Drives Aging-Related Functional Decline in a Subpopulation of the Hematopoietic Stem Cell Compartment. Cell Rep 19(8):1503-1511 |
| abstractText | Aging of the hematopoietic stem cell (HSC) compartment is characterized by lineage bias and reduced stem cell function, the molecular basis of which is largely unknown. Using single-cell transcriptomics, we identified a distinct subpopulation of old HSCs carrying a p53 signature indicative of stem cell decline alongside pro-proliferative JAK/STAT signaling. To investigate the relationship between JAK/STAT and p53 signaling, we challenged HSCs with a constitutively active form of JAK2 (V617F) and observed an expansion of the p53-positive subpopulation in old mice. Our results reveal cellular heterogeneity in the onset of HSC aging and implicate a role for JAK2V617F-driven proliferation in the p53-mediated functional decline of old HSCs. |
