| First Author | Cheng D | Year | 2017 |
| Journal | Nat Immunol | Volume | 18 |
| Issue | 2 | Pages | 205-213 |
| PubMed ID | 27992403 | Mgi Jnum | J:259481 |
| Mgi Id | MGI:6141970 | Doi | 10.1038/ni.3642 |
| Citation | Cheng D, et al. (2017) Themis2 lowers the threshold for B cell activation during positive selection. Nat Immunol 18(2):205-213 |
| abstractText | The positive and negative selection of lymphocytes by antigen is central to adaptive immunity and self-tolerance, yet how this is determined by different antigens is not completely understood. We found that thymocyte-selection-associated family member 2 (Themis2) increased the positive selection of B1 cells and germinal center B cells by self and foreign antigens. Themis2 lowered the threshold for B-cell activation by low-avidity, but not high-avidity, antigens. Themis2 constitutively bound the adaptor protein Grb2, src-kinase Lyn and signal transducer phospholipase gamma2 (PLC-gamma2), and increased activation of PLC-gamma2 and its downstream pathways following B cell receptor stimulation. Our findings identify a unique function for Themis2 in differential signaling and provide insight into how B cells discriminate between antigens of different quantity and quality. |
