| First Author | Ma Y | Year | 1995 |
| Journal | J Biol Chem | Volume | 270 |
| Issue | 1 | Pages | 483-93 |
| PubMed ID | 7814415 | Mgi Jnum | J:22307 |
| Mgi Id | MGI:70188 | Doi | 10.1074/jbc.270.1.483 |
| Citation | Ma Y, et al. (1995) Cloning and expression of a novel truncated calcium channel from non-excitable cells. J Biol Chem 270(1):483-93 |
| abstractText | Calcium entry, via a dihydropyridine-sensitive pathway, is required for differentiation in murine erythroleukemia cells (MELC). Calcium channel currents have been identified physiologically in some non-excitable cells, but little is known regarding the structure of these channels. We show that a truncated form of the alpha 1 subunit of the cardiac voltage-gated calcium channel (dihydropyridine receptor, DHPR) is expressed in MELC. This MELC calcium channel lacks the first four transmembrane segments of the DHPR (IS1 to IS4). A MELC calcium channel/cardiac DHPR chimera, co-expressed with the alpha 2 and beta subunits of the DHPR, forms a functional calcium channel in Xenopus oocytes. |
