| First Author | Morimoto BH | Year | 1991 |
| Journal | Genes Dev | Volume | 5 |
| Issue | 12B | Pages | 2386-91 |
| PubMed ID | 1752434 | Mgi Jnum | J:2330 |
| Mgi Id | MGI:50854 | Doi | 10.1101/gad.5.12b.2386 |
| Citation | Morimoto BH, et al. (1991) Molecular cloning of a member of a new class of low-molecular-weight GTP-binding proteins. Genes Dev 5(12B):2386-91 |
| abstractText | We report the cloning of a low-molecular-weight GTP-binding protein that appears to be the first member of a new class of G proteins. This G protein was cloned from the HT4 neural cell line and has the closest homology to the rab, sec4, and ypt1 members of the low-molecular-weight (LMW) G-protein family. The amino acid sequence identity is only 30% with these other LMW G proteins, but in the four conserved GTP-binding domains, amino acid identity increases to 50-100%. A unique feature that distinguishes this G protein from other LMW G proteins is its carboxy-terminal amino acid sequence -Cys-Cys-Pro. In keeping with the current nomenclature for other members of the ras superfamily, we will designate this new class as rah (ras-related homolog). On the basis of sequence homology, rah may function in vesicular trafficking and possibly in neurotransmitter secretion. |
