| First Author | Sakaguchi S | Year | 2000 |
| Journal | Curr Opin Immunol | Volume | 12 |
| Issue | 6 | Pages | 684-90 |
| PubMed ID | 11102773 | Mgi Jnum | J:65819 |
| Mgi Id | MGI:1927332 | Doi | 10.1016/s0952-7915(00)00163-1 |
| Citation | Sakaguchi S (2000) Animal models of autoimmunity and their relevance to human diseases. Curr Opin Immunol 12(6):684-90 |
| abstractText | T cells mediate various autoimmune diseases. Pathologic autoimmunity can be induced by manipulating thymic or peripheral control of self-reactive T cells. There is, for example, accumulating evidence that elimination or dysfunction of regulatory T cells can elicit T cell mediated, destructive autoimmune disease in otherwise normal animals and enhance autoimmunity in spontaneous models. |
