| Primary Identifier | MGI:1344380 | Organism | mouse, laboratory |
| Chromosome | 6 | NCBI Gene Number | 107932 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.0.0) Enables DNA-binding transcription factor binding activity. Predicted to be involved in several processes, including double-strand break repair via homologous recombination; negative regulation of macromolecule biosynthetic process; and terminal button organization. Predicted to act upstream of or within chromatin organization. Located in nucleus. Part of NuRD complex. Is expressed in several structures, including alimentary system; branchial arch; genitourinary system; hemolymphoid system; and nervous system. Used to study left ventricular noncompaction. Human ortholog(s) of this gene implicated in colorectal cancer (multiple); lung cancer (multiple); and lymphoma. Orthologous to human CHD4 (chromodomain helicase DNA binding protein 4). PHENOTYPE: Mice homozygous for a gene trapped allele exhibit embryonic lethality between E3.5 and E4.5, absent blastocoele failure of trophectoderm function and increased apoptosis in blastocysts. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
